摘要
目的:研究肢体缺血预处理(LIP)对大鼠缺血再灌后心脏损伤的影响。方法:采用反复捆绑后肢造成缺血预适应的方法,观察其对心肌缺血再灌后梗死面积和形态学改变的影响,对心肌CK-MB和cTn-I的影响,以及对抗氧化物酶的影响。结果:与缺血再灌组比较,预处理能明显降低心肌梗死面积,减轻心肌细胞的损害,减少心肌酶的漏出并能提高SOD的活性。结论:LIP对心肌损伤具有保护作用。
Objective：To investigate the effect of limb ischemic preconditioning（LIP）on the myocardial ischemia-reperfusion（I/R）injury in rats. Methods： By ischemic preconditioning in hind limb to make the model, then investigate the effect on myocardial infarct size and morphologic change,and also on the enzyme of CK-MB and cTn-I. The activity of SOD after myocardial I/R was observed as well. Results：Compared with I/R,the myocardial infarct size was reduced, the myocardial injury was attenuated, the leakage of CK-MB and cTn-I was decreased and the activity of SOD was increased after pretreated with LIP. Conclusion： LIP has protection function on myocardial injury.
出处
《河北北方学院学报（医学版）》
2008年第3期7-10,共4页
Journal of Hebei North University:Medical Edition
