牙周病患者前列腺素E_2与各临床指标的相关性研究

The relativity between PGE2 in gingiva of periodontal disease and periodontal disease index

目的：探讨牙龈组织中ＰＧＥ２与牙周病各临床指标的相关性。方法：用放射免疫测定法（ＲＩＡ）分析不同牙周病患者牙龈组织中ＰＧＥ２含量，并测定和分析实验牙龈沟液量（ＧＣＦ）和牙周病各临床指数与龈组织中ＰＧＥ２的关系。结果：ＡＰ患者龈组织中ＰＧＥ２与ＧＣＦ、ＰＤ和ＡＬ呈正相关；ＪＰ患者龈组织中ＰＧＥ２与ＧＣＦ和ＡＬ呈显著性正相关，与ＰＤ呈正相关，ＡＰ和ＪＰ患者ＧＣＦ与ＰＤ、ＡＬ呈正相关，ＰＤ与ＡＬ呈显著性正相关；Ｇ患者龈组织中ＰＧＥ２与ＧＩ，ＧＣＦ与ＰＤ均呈显著性正相关。结论：ＡＰ患者的ＧＣＦ、ＰＤ和ＡＬ可近似代表ＰＧＥ２含量，ＪＰ患者的ＧＣＦ和ＡＬ可较好地反映ＰＧＥ２含量，Ｇ患者龈组织中的ＰＧＥ２可用ＧＩ代替。

Aim: To study the relativity between PGE2 in gingiva of periodontal disease and periodontal disease index. Methods: The contents of PGE2 in gingiva of different periodontal disease was analysed by radioimmunoassay and measured the gingival crevicular fluid(GCF) and periodontal disease index of experiment teeth. Results: The PGE2 in gingiva of Adult periodontitis(AP) was related to GCF, Pocket Deep(PD) and Attachment Loss(AL)(P<0.05). The PGE2 in gingiva of Juvenile Periodontitis(JP) was notable positive interrelated to GCF and AL(P<0.01), and was positive related to PD. The GCF of periodontitis was bound up with PD and AL, its PD was related to AL. The PGE2 in gingiva of gingivitis(G) was marked related to GI, and its GCF was notable related to PD. Conclusions: The PD, AL, GCF of AP can approximately represent its contents of PGE2 in gingiva; the GCF and AL of JP can represent its PGE2 contents in gingiva better; the PGE2 contents in gingiva of G can be replaced by GI.