大分子载5-氟尿嘧啶药物及其缓释性研究进展

5-Fluorouracil Drugs Delivered by Macromolecular and Their Developments in the Research of Slow-releasing

5-氟尿嘧啶是一种不可取代的最有效抗肿瘤药物之一,为了克服其毒副作用较大的缺点,将5-FU连接在天然高分子、化学合成高分子和微生物产生的高分子载体上,制成前药,并进行抗癌活性、缓释性、靶向性研究已成为药物传输、载运和释放研究领域最前沿和热点课题之一。

5-fluorouracil is one of the best and unreplacable anti-cancer drugs. In order to reduce its side-effect of high toxicity, attemps to connect 5-fluorouracil onto natural macromolecular, synthetic macromolecular and macromolecular produced by microbiological species become hot topic and frontline in the research field of pre-drugs. So that scientists are able to look at details in the anti-cancer activities, slow-releasing and targeting. Those activities have been drawn much attention in the field of drug-delivery, transportation in the body and releasing to the target cells.