基因芯片在农药毒理学中的应用

Application of DNA Microarray in Pesticide Toxicology

概述了传统农药毒性评价方法的不足,阐述了基因芯片的优势及其在农药毒理学中的主要用途,即通过检测分子水平上发生的变化来洞察毒物的作用机制及其对人体构成危害的潜在原因,在免去许多不必要生物试验的同时提供更多有价值的信息,提高新药研发效率,更加真实反映人体对化学物的反应。希望该技术能尽早的应用于农药毒理学的各方面。

The problems faced by traditional approaches for assessing toxicity were discussed, meanwhile, the advantage of DNA microarray and its application in pesticide toxicology was introduced. The new approach should provide more insight into potential human toxicity than current methods. DNA microarray, the examination of changes in gene expression following exposure to a toxicant, offers the potential to identify a human toxicant earlier in drug development and to detect human-specific toxicants that cause no adverse reaction in rats.