心肺复苏患者血清S100β蛋白的动态变化及其临床意义

Changes and clinical significance of serum S100β in cardiopulmonary resuscitated patients

目的探讨心肺复苏患者血清S100β蛋白的动态变化及其临床意义。方法对67例心跳、呼吸骤停的患者进行标准心肺复苏，动态检测67例心搏骤停复苏患者和33例对照者血清S100β蛋白水平。结果S100β蛋白在心肺复苏不同时间30、45min、1、2、8、24、48、72h有脑损伤和无脑损伤者比较，P〈0．05，差异有统计学意义。自主循环恢复后2h伴有脑损害者S100β蛋白为（4．2±0.7）μg／L，没有恢复自主循环者S10013蛋白为（3．5±0．5）μg／L，而没有脑损伤者为（0．8±0．5）μg／L，差异有统计学意义。结论心搏骤停自主循环恢复后血清S100β蛋白水平明显升高，这是早期判断心搏骤停复苏后有否脑损伤的敏感指标。

Objective To investigate the changes and clinical significance of serum S100β in cardiopulmonary resuscitated patients. Methods Serum S100β concentrations were detected by ELISA in 67 patients with cardiac and respiratory sudden arrest treating with standard cardiopulmonary resuscitation and 33 normal control group, and dynamic detecting the level of blood S100β of cardiopulmonary resuscitated patients. Results Blood samples in 67 patients were taken for the determination of S100β. Maximum S100β levels within 2 hours after cardiac arrest were significantly higher in patients with documented brain damage [ surviors and nonsurviors, （4. 2 ± 0. 7 ）μg/L ] than in patients without brain damage [ （0.8 ±0.5） μg/L]. Significant differences between these two groups were observed from 30 minutes until 72 hours after cardiac arrest. Conclusion Astroglial protein S100β is an early and sensitive marker of hypoxic brain after cardiac arrest in humans.