尿路感染病原菌分布及耐药性分析

Distribution and drug resistance in urinary infection

目的了解我院尿路感染病原菌的分布及体外耐药性，为临床提供诊断与治疗依据。方法对我院2006年1月至2007年12月尿培养分离出的273株细菌的种属分布及耐药性进行分析。结果大肠埃希氏菌是引发尿路感染的主要病原菌，占38．1％；其次是凝固酶阴性葡萄球菌（14．3％）、肠球菌（12，5％）、真菌（11．7％）、肺炎克雷伯氏菌（7．0％）、奇异变形杆菌（5．5％）及铜绿假单胞菌（5．1％）；药敏试验结果显示除肠杆菌科细菌对亚胺培南，肠球菌属和葡萄球菌属细菌对万古霉素100％敏感外，对其他抗菌药物都有较高的耐药性。结论大肠埃希氏菌是尿路感染的最主要病原菌，临床医生应注意其耐药性变化，合理应用抗菌药物。

Objective To investigate the distribution and drug resistance of pathogensin urinary system infection. Methods Two hundred and seventy three strains collected from patients urine specimens of our hospital during Jan. 2006 to Dec. 2007 were cultrured to detect and were sdudied drug resistance. Results Among these pathogens, Eseherichia coli rated the top one（ 38.1% ） , followed by coagulase negative Staphylococcus （ 14. 3% ）, Enterococcus （ 12. 5% ）, Fungus （ 11.7% ）, Klebsiella pneumoniae （ 7.0% ）, Pmirabilis （5.5%） ,and Pseudomonas aeruginosa （5.1%）. Enterobacteriaceae sensitived to imipenen （100%）, Enterococcue and Staphytococcus sensitived tovancomycin（ 100% ）. But they showed higher drug resistance to other antibiotics. Conclusion Eseherichia coli is the main infectious bacterium in urinary system infection. Clinician should pay attention to the changes of their drug resistance and use correctely.