慢性乙肝患者血清sICAM、IFN-γ水平相关性研究

Correlation Study of Serum sICAM-1 and IFN-γ Levels in Patients with Chronic Hepatitis B

目的了解深圳市慢性乙形肝炎基因型流行病学特点,以及不同基因型患者血清可溶性细胞间黏附分子(sICAM-1),干扰素-γ(IFN-γ)水平情况,探讨其可能的临床意义,比较不同基因型患者血清sICAM-1和IFN-γ水平。方法选择慢性乙肝、乙肝后肝硬化患者146例,对照组102例,分别检测其肝功、sICAM-1、IFN-γ和基因型。结果患者基因型以B型为主82例(56.2%),其次是C型44例(30.1%),此外BC混合型17例(11.6%),D型3例(2.1%)。sICAM-1慢性乙肝中、重度组和肝硬化组较对照组明显升高,IFN-γ重度组和肝硬化组较对照组明显升高。sICAM-1与IFN-γ显著正相关,它们与谷丙转氨酶(ALT)、谷草转氨酶(AST)、直接胆红素(DB)正相关,IFN-γ还与总胆红素(TB)正相关。sICAM-1水平C型较B型患者高。结论病毒性肝炎及肝硬化患者血清sICAM-1和IFN-γ升高与肝细胞损伤有关,C型患者血清sICAM-1水平较B型高。

Objective To study the epidemiological characteristics of genotype of hepatitis B virus （HBV） in Shenzhen; to determine the possible clinical significance of serum sICAM - 1 and IFN - γthrough estimating their levels in chronic hepatitis B patients; and to study if different genotype of hepatitis B virus has an impact. Methods Totally 146 patients with chronic hepatitis B and/or cirrhosis and 102 healthy controls were enrolled in this study. Liver function, the levels of sICAM 1 and IFN- γ, and the genotype of HBV were assessed. Results Among the 146 patients, 56.2 % （82/146） were genotype B, 30.1% （44/146） were genotype C, 2.1% （3/146） genotype D, and 11,6 % （17/146） B and C mixed .infection. Experiments showed that the level of sICAM - 1 was significantly higher in the groups of moderate, severe chronic hepatitis B and cirrhosis than that of the control group; and the level of IFN - γ was significantly higher in the groups of severe chronic hepatitis B and cirrhosis than that of the control group. There were positive correlations between sICAM - 1 and IFN - γ, anci between sICAM - 1, IFN - γ and ALT, AST, TB, and between IFN - γ and TB. Genotype C patients had a higher serum level of slCAM 1 than genotype B patients＇. Conclusions The levels of sICAM - 1 and IFN- γ are associated with hepatocyte injury. Genotype C patients.have a higher serum level of sICAM - 1 than that of genotype B patients.