心理行为干预与卵巢癌患者T淋巴细胞亚群的动态变化

Psycho-behavior Intervention and Changes of Immune Function in Patients with Ovarian Cancer

目的:探讨心理行为干预对卵巢癌患者T淋巴细胞亚群功能影响的动态变化,并进一步探讨心理干预的最佳时间。方法:运用病例对照实验设计,对62例卵巢癌患者进行比较研究。用免疫组化碱性磷酸酶桥联酶标法(A-PAAP)测定心理行为干预前及心理行为干预后一个月、二个月、三个月的T淋巴细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+数值的动态变化。结果:心理行为干预一个月后CD3+、CD4+有显著性提高;干预2个月后各免疫参数均有显著变化,且干预2个月与3个月相比各免疫参数变化不明显。干预组与对照组相比,不同时间点的各种免疫参数有显著性差异(P<0.05),干预与时间点见明显的交互作用(P<0.05),除CD8+(P>0.05)外,两组患者各免疫参数存在显著性差异。结论:心理行为干预可以提高卵巢癌患者T淋巴细胞亚群的免疫功能,且干预2个月后患者免疫功能维持在较高水平。

Objective： To examine the effects of the psychological intervention on immune function in ovarian cancer and further explore the best time. Methods： 62 inpatients were randomly assigned to either intervention group or control group. Immune parameter variables in both groups were measured four times （before and 1,2,3 months after psychological intervention）. Results： CD3^＋ 、CD4^＋ were increased significantly after psychological intervention for one month; All immune parameters were increased significantly after psychological intervention for two months, but no significant differences between two and three months. Difference between two groups were significant （P〈0.05） at different time; interaction between intervention and time were also significant （P〈0.05）, except CD8^＋, all immune parameters were increased significantly. Conclusion： These data suggest that immune function can be improved in patients with ovarian cancer,which remained at a relatively high level after psychological intervention for two month.