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CD25mAb及联合供体脾细胞诱导心脏移植免疫低反应性 被引量:1

The Induction of Hyporesponse to Heart Allografts by Vein Injecting of CD25mAb or Associated with Donor Splenocytes
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摘要 目的观察静脉应用CD25mAb及联合应用供体脾细胞对移植心脏生存时间的影响。方法建立大鼠异位心脏移植模型,术中应用CD25mAb及联合应用供体脾细胞。术后通过腹壁触诊判断移植心脏存活情况。结果CD25mAb组移植心脏生存时间为12.10±4.04天,与未用药组(8.5±2.42天)相比差异有显著性意义(P<0.05)。CD25mAb+供体脾细胞组移植心脏生存时间为12.80±3.61天,与单独应用CD25mAb组相比没有明显差异(P>0.05),但比单独用脾细胞组(8.40±3.50天,P<0.05)和未用药组有明显延长(P<0.05)。结论静脉应用CD25mAb及联合应用供体脾细胞均可以延长移植心脏生存时间。 Objective To observe the heart aUografts survival time after administration of immunosuppressive agents CD25mAb or associated with donor splenocytes in a single dose on the time of operation. Methods A simplified heterotopic rat heart transplantation model was established and the CD25mAb (1mg/kg) were injected through vein or associated with donor splenocytes (1× 10^9 cells/100g). The grafts survival was observed by palpating over the abdominal wall postoperation. Results In using CD25mAb group, the average of the survival of heart allograft was 12.10 ± 4.04 days, which had a significant difference compared with those of the no therapy group (8.5 ± 2.42 days, P〈0.05). In using CD25mAb+donor splenocytes group, the average survival of heart allografts is 12.80 ±3.61 days, which had no significant difference with those of using CD25mAb alone (P〉0.05), and much longer than those of using donor splenocytes group (8.40 ±3.50 days, P〈0.05) and no therapy group (P〈0.05). Conclusion The findings demonstrate that a single injection of CD25mAb or associated with donor splenocytes can induce stable longterm acceptance of heart allografts.
出处 《罕少疾病杂志》 2008年第3期3-5,共3页 Journal of Rare and Uncommon Diseases
关键词 CD25单克隆抗体 脾细胞 心脏移植 CD25mAb splenocytes heart transplantation
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