高血压患者脉压与尿微量白蛋白的关系探讨

Relalionship of Pulse Pressure with Urinary Microalbuminuria in Patients with Essential Hypertension

目的:探讨高血压患者脉压与尿微量白蛋白(UmALB)排泄量的关系。方法:选取80例原发性高血压患者,据脉压(PP)水平分成PP<9.33 kPa组38例和PP≥9.33 kPa组42例。两组均予系统降压治疗1月,血压达标(BP<18.67/12 kPa)后注意观察3月,分析这些患者治疗前后PP及UmALB的变化,并进行比较。结果:PP<9.33 kPa组治疗前后UmALB量无明显变化,PP≥9.33 kPa组治疗后有37例血压达标,该组总的UmALB分泌量减少,其中治疗后PP<9.33 kPa组病例比治疗后PP≥9.33 kPa组病例的UmALB的分泌量明显减少(P<0.05)。结论:随着脉压的降低,尿微量白蛋白排泄量显著下降,故脉压增大是高血压患者早期肾功能损害的预测因素。

Objective：To disscuss the relationship between pulse pressure（PP） and excretion of urinary microprotion（UmALB） in patients with essential hypertension. Methods： To select 80 patients with essential hypertension, to divide into two groups according to the PP level. One had 38 patients PP 〈 9.33 kPa,the other had 42 patients with PP ≥9.33 kPa,All patients of two groups were given the same normal treatment for one month. After the blood pressure（BP） normal（ BP 〈 18.67/12 kPa） to continuous observe 3 monthes. Results： There was no obvious change about the UmALB in PP 〈 9.33 kPa group before and after treatment. After the treatment there were 37 cases who＇s BP reach the normal in the group of PP≥9.33 kPa , the total UmALB excretion reduced. The UmALB excretion of PP 〈 9.33 kPa group was less than PP ≥ 9.33 kPa group after treatment, the difference was remarkable （ P 〈 0. 05 ）. Conclusions： With the PP reduction, UmALBs excretion drops, therefore, the increase of PP is a predictor of early renal damage.