mTOR信号传导通路及运动对其影响的分子机制综述

mTOR signal conduction paths and their motion affecting molecular mechanism

从mTOR的分子结构着手,综述了以mTOR为中心的4条信号传导通路(2条mTOR上游信号通路、2条mTOR下游信号通路)。这些信号通路在运动影响骨骼肌的信号传导过程当中发挥着举足轻重的作用。所有这些引起骨骼肌质量变化的信号系统,都是以mTOR为中心的,交互联系,构成一个统一的信号传导网络。一方面,运动引起骨骼肌肥大受到PI3K/Akt/mTOR和PI3K/Akt/TSC12/mTOR两条通路影响;另一方面,运动引起骨骼肌萎缩受到AMPK/TSC2/mTOR信号传导通路影响。

By working on the molecular structure of mTOR, the authors gave an overview of 4 signal conduction paths （2 mTOR upstream signal paths and 2 mTOR downstream signal paths） that base their center on mTOR. These signal paths play a critical role in the process of signal conduction of motion affecting the skeletal muscle. All these signal systems that cause the change of quality of the skeletal muscle are basing their center on mTOR, and interactively connected to form a unified signal conduction network. On the one hand, kinetic skeletal muscle hypertrophy is affected by such two paths as PI3K/Akt/mTOR and PI3K/Akt/TSC 12/mTOR; on the other hand, kinetic skeletal muscle atrophy is affected by such a signal conduction path as AMPK/TSC2/mTOR.