老年肝硬化患者不同类型食物胃排空时间与血清NO关系初步探讨

A preliminary study of relationship between gastric emptying time of different type foods and serum nitric oxide in old patients with liver cirrhosis

目的研究老年肝硬化患者不同类型食物胃排空时间及其与血清NO水平关系。方法分别应用实时超声法和放射学方法对30例老年肝硬化患者(Child-Pugh A级9例,B级13例,C级8例)和30例健康志愿者进食液体和半固体食物后胃排空时间进行测定,并测定其空腹血清NO浓度。结果肝硬化患者胃液体半排空时间为47.3±6.9min,而进食10mm小钡条和半固体标准餐混合物后胃排空时间为6.9±1.9 h;健康对照组则分别为26.4±5.3min和4.7±1.1h。血清NO浓度患者组与对照组分别为67.9±7.3umol/L及48.8±6.2umol/L,差异均有统计学意义。而Child A,B,C三组之间差异无统计学意义。结论老年肝硬化患者不同类型食物胃排空时间均有延迟,NO在动力延缓中可能起着重要的作用。实时超声法和放射学方法简单有效。

Objective To study the relationship between gastric emptying time of liquid or semi-solid foods and serum nitric oxide （NO） in old patients with liver cirrhosis. Methods Liquid and semi-solid foods mixed with 10 small barium bars as markers were taken by 30 old patients with liver cirrhosis （Child A, 9 cases; Child B, 16 cases, and Child C, 5 cases） and 30 volunteers. Real time ultrasonography and digital radiography were used for the estimation of gastric emptying time （GET）. Fasting serum NO was also tested. Results In patients with liver cirrhosis, semi-GET of liquid foods was 47.3±6.9min, GET of semi-solid foods was 6.9± 1.9 h, and their serum NO was 67.9±7.3umol/L, versus 26.4±5.3min, 4.7±1. lh and 48.8±6.2umol/L in volunteers. There was significant difference between patients and volunteers, but there was no significant difference between Child-Pugh A, B, C patients. Conclusions Unlike volunteers, semi-GET of liquid foods and GET of semi-solid foods were delayed in old patients with liver cirrhosis. NO probably plays an important role in the abnormality of gastric emptying. Real time ultrasonography and radiography are simple and effective methods for assessment.