茶多糖对高脂血症大鼠血脂及肝脏中微量元素的调节作用

EFFECTS OF TEA POLYSACCHARIDES ON BLOOD LIPIDS AND LIVER TRACE ELEMENTS IN HYPERLIPIDEMIC RATS

目的考察3种纯度的茶多糖(TPS):TPSI(含27.43%TPS)、TPSⅡ(含57.82%TPS)和TPSⅢ(含89.50%TPS)对高脂血症大鼠的治疗作用以及对大鼠肝脏中微量元素含量的影响。方法高血脂症模型大鼠分别灌胃不同纯度的TPS4w,测定大鼠血清中胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、丙二醛(MDA)含量和肝脏中Ca、Fe、Zn、Cu、Mg等元素的含量。结果实验组大鼠血清TC、MDA含量与模型组相比显著降低(P<0.05),HDL-C、LDL-C没有显著变化,肝脏中Zn、Cu、Mg含量和Zn/Cu比值变化与模型组比较变化显著(P<0.01)。结论TPS具有一定的降低大鼠血脂作用,具有很好的体内抗氧化作用,并且能够调节其肝脏中与脂代谢有关的Zn、Cu、Mg含量和Zn/Cu比值趋于正常水平。

Objective To investigate the effects of tea polysaccharides （TPS） on blood lipids and liver trace elements in hyperlipidemic rats. Method The hyperlipidemic rats were treated by gavage with tea polysaccharides of three purities, named TPS Ⅰ, TPS Ⅱ, and TPS Ⅲ at 27.43%, 57.82%, and 89.50% purity, respectively for 4 w. Then the rats were killed and the influence of TPS on concentrations of total cholesterol （TC）, triglyceride （TG）, low-density lipoprotein cholesterol （LDL-C）, high-density lipoprotein cholesterol （HDL-C）, malondialdehyde （MDA） in blood serum, and Ca, Fe, Zn, Cu and Mg ion in liver were determined. Results The TC and MDA concentrations in blood serum of the experimental rats decreased significantly （P〈0.05） compared with model group. But HDL-C, LDL-C concentrations were not significantly changed. The Zn, Cu, Mg and Zn/Cu contents in the liver in TPS groups were changed significantly （P〈0.01） compared with model group. Conclusion TPS had cholesterol reducing and antioxidative effect, and regulated the level of liver Zn, Cu, Mg and Zn/Cu in hyperlipidemic rats.