磺胺多金属氧酸盐对人宫颈癌Hela细胞的抑制作用

Inhibitive Effect of Polyoxometalate Containing Sulfanilamide on Human Cervical Carcinoma Hela Cells

对磺胺多金属氧酸盐（C6H9N2O2S）5HP2Mo18O62·15H2O（SPOM-1），（C6H9N2O2S）H8P2Mo15V3O62·8H2O（SPOM-2）进行了体外毒性实验和抑制宫颈癌Hela细胞作用的研究．当SPOM浓度为50—100mg·L^-1时，对人胚胎成纤维细胞均无细胞毒性作用（P〉0．05），TC50分别为459mg·L^-1、295mg·L^-1；抑制宫颈癌He—la细胞的EC50分别为88mg·L^-1、24mg·L^-1，治疗指数即分别为5．22，12．29．

Toxicity test in vitro and research on inhibitive effect of polyoxometalate containing sulfanilamide （C6H9N2O2S）5HP2Mo18O62· 15H2O （SPOM-1） and （ C6H9N2O2S） HsPzMo18V3O62- 8H2O （SPOM-2） were performed. It is shown from the toxic test in vitro that there is not the cytotoxic effect on human embryo fibroblasts （P 〉 0.05）, when the compound concentration is 50 - 100 mg· L^-1. The TC50 are 459 mg· L^- 1 and 295 mg· L ^- 1, respectively; the EC50 of inhibitive effect on cervical carcinoma Hela cells are 88 mg· L^-1 and 24 mg· L^-1; and the therapeutic index are 5.22 and 12.29.