摘要
目的探讨慢性锑中毒患者细胞因子水平与抗氧化能力的相关性。方法对慢性锑中毒患者和对照组血清白细胞介素-2(IL-2)、白细胞介素-8(IL-8)、肿瘤坏死因子α(TNF-α)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)水平进行检测及分析。结果与对照组相比,慢性锑中毒患者血清IL-2I、L-8和TNF-α水平显著增高(P<0.01),SOD、GSH-Px活性明显降低,而MDA水平增高(P<0.01)。锑中毒患者IL-2I、L-8、TNF-α含量与SOD、GSH-Px活性呈负相关(P<0.01),与MDA水平呈正相关(P<0.01)。结论慢性锑中毒患者的细胞因子水平随抗氧化能力的降低而升高。
Objective To study the relationship between cytokine levels and anti-LiPid peroxidation ability in chronicity Antimony Poisoning Patients. Methods Interleukin-2 (IL-2),Interleukin-8(IL-8), tumornecrosis factor-α (TNF-α), superoxide dismutase(SOD),glutathione peroxidase(GSH-px) and malondialdehyde(MDA)in the serum of patients with chronicity Antimony Poisoning were measured and analyzed. Results Comparing with those of the control group, the IL-2, IL-8,TNF-α, MDA levels were higher( P 〈0.01 ), while the SOD, GSH-Px Contents were lower ( P 〈0.01) in the patients chronicity Antimony Poisoning. there was a negative correlation between the content of IL-2,IL-8,TNF-α had a negative correlation with SOD,GSH-Px, while they had a significant positive correlation with MDA. Conclusion the eytokine levelswould increase as the decrease of anti-LiPid peroxidation ability in ehronieity Antimony Poisoning Patients.
出处
《右江医学》
2008年第3期247-249,共3页
Chinese Youjiang Medical Journal
基金
贵州省卫生厅科技资助项目[黔卫发(2004)156号]
关键词
慢性锑中毒
细胞因子
抗氧化能力
ehroniety
Antinmony Poisoning
cytokine
anti-lipid peroxidation.