IL-10、IFN-γ在外阴阴道念珠菌病患者发病中的作用

Effection of Interleukin-10 and Interferon-gamma with pathogenesis of Vulvovaginal Candidiasis Patients

目的检测白细胞介素-10(IL-10)、干扰素-γ(IFN-γ)在正常女性、外阴阴道念珠菌病及复发性外阴阴道念珠菌病阴道分泌物中的表达水平。探讨细胞因子IL-10和IFN-γ的表达水平与外阴阴道念珠菌病发病的关系。方法ELISA法检测初发组和复发组念珠菌性阴道炎的妇女阴道分泌物中IL-10、IFN-γ的表达水平,以健康体检妇女为对照组。结果初发和复发念珠菌性阴道炎的阴道分泌物中IL-10的表达水平均显著高于对照组,复发组较初发组的表达水平也有显著性差异(P<0.05);初发和复发念珠菌性阴道炎的阴道分泌物中IFN-γ的表达水平无显著性差异(P>0.05),但均高于健康对照组(P<0.05)。结论Th1型和Th2型细胞因子的表达异常可能与念珠菌性阴道炎发病和复发有关。

Objective To detect the level of interleukin-10（IL-10） and interferon-gamma（IFN -γ） in the vaginal secretions of vulvovaginal eandidiasis patients and to investigate their relationship with the pathogenesis of vulvovaginal eandidiasis. Methods The expression level of the IL-10 and IFN-γ in the vaginal secretions from vulvovaginal eandidiasis patients was detected by ELISA and compared with that from normal controls. Results The level of IL-10 and IFN-γ in both incipient and relapse groups of vulvovaginal eandidiasis were significantly higher than that in control group （both P〈0. 05） ; the level of IL-10 in relapse group was higher than in incipient group, There was no significant difference of IFN-γlevel between incipient and relapse group （ P 〉 0. 05） . Conclusion The abnormal expression of the Th1 and Th2 cytokines might participate in the pathogenesis and the recrudescence of vulvovaginal candidiasis.