新型生物材料聚(乳酸-苯丙氨酸)的直接熔融聚合法制备与表征

Direct Synthesis of Novel Biomaterial Poly(lactic acid-co-Phenylalanine) via Melt Copolycondensation and Its Characterization

直接以廉价的外消旋乳酸（D，L—LA）和苯丙氨酸（Phe）为原料，以氧化亚锡为催化剂，采用熔融聚合法合成了新型生物材料聚（乳酸一苯丙氨酸）共聚物。用特性粘数[η]、FTIR、‘HNMR、DSC、GPC、XRD等进行系统表征，并考察了不同投料比对共聚物的影响。随着投料比中苯丙氨酸含量n（Phe）的增加，共聚物由一定的结晶性逐渐转变为无定形态。所得共聚物的Mw在2700～3900之间，能满足该生物降解材料在药物缓释领域中的应用。

Using cheap D, L - lactic acid （ D, L - LA） and phenylalanine （Phe） as material, and SnO as catalyst, novel biomaterial poly（ lactic acid - co - phenylalanine） [ P（ LA - co - Phe） ] was directly synthesized via melt eopolycondensation. The copolymer was systematically characterized with intrinsic viscosity [η], FTIR, 1H NMR, DSC, XRD and GPC. The effects of different feed molar ratio were discussed. With the increase of the feed molar ratio of Phe, the crystallinity of copolymer gradually disappeared. Their weight - average molecular weight （Mw） was between 2700 and 3900, which could meet the request for the application in drug delivery of this biodegradable material.