摘要
以L-天冬氨酸为原料经过酯化、消旋、拆分和水解制备D-天冬氨酸。使L-2，3-二苯甲酰酒石酸（L—DBTA）与DL-天冬氨酸-β-甲酯在水溶液中于65—70℃反应形成非对映体盐，冷却到室温，D-天冬氨酸·L—DBTA盐析出，过滤后再经水解得到D-天冬氨酸，收率78．2％，旋光纯度达到99％以上。
A new method for the preparation of D - aspartic acid from L - aspartic acid by esterfication, racemization, resolution and hydrolyzation is reported. Reaction of L- 2,3 -dibenzoyl tartaric acid with DL- aspartic acid- β -methyl ester in aqueous solution at 65 -70℃ formed diastreroisomeric salts,from which D -aspatic acid - β - methyl ester L - 2,3 - dibenzoyl tartarate was precipitated when the mixture was cooled to room temperature. The salt was hydrolyzed giving D - aspartic acid with yield of 78.2%, and optical purity of 99%.
出处
《氨基酸和生物资源》
CAS
2008年第2期33-35,共3页
Amino Acids & Biotic Resources
