IL-6在早孕绒毛蜕膜中的表达及米非司酮对其的影响

The effect of mifepristone on the expression of IL-6 in human decidua and chorion of early pregnancy

目的观察IL-6在早孕绒毛、蜕膜组织中的表达及米非司酮对其表达的影响,探讨药物流产的分子免疫作用机制。方法采用免疫组化染色测定早孕绒毛及蜕膜组织中IL-6的表达,其中正常早孕人工流产组20例,米非司酮药物流产组22例。结果IL-6在正常早孕绒毛及蜕膜组织中均呈阳性表达,米非司酮药物流产组表达强度明显降低(P<0.01)。结论IL-6在早孕绒毛及蜕膜中有较高水平表达,可能与胚泡着床、妊娠维持有关,米非司酮明显降低其表达,影响胚胎发育引起流产。

Objective To study the effects of mifepristone on the expression of IL-6 in human decidua and chorion of early pregnancy in order to explore the molecular immune mechanism of mifepristone-inducedabortion. Methods The expression of IL-6 in chorion villi and decidua of normal early pregnancy （20 cases） and mifeprisone-induced abortion （22 cases） were examed by using immunohistochemical technique. Results The expression of IL-6 was observed in all the chorion villi and decidua of normal early pregnancy , and the expression of IL-6 in mifepristone group was significantly lower than that of normal early pregnancy group（ P 〈 0.01）. Conclusion The expression of IL-6 may be associated with embryo implantation and eary pregnancy maintenance. Mifepristone properly affects the growth of embryo by reducing the expression of IL-6.