Z径路肌内注射法与常规肌内注射法临床效果的Meta分析

Clinical Effects of Z-track Intramuscular Injection and Routine Intramascular Injection:A Meta Analysis

目的 对Z径路（Z—track）肌内注射法和国内常规肌内注射法进行比较研究。方法 采用Meta分析方法，通过计算机检索国内有关两种注射法的病例对照研究，将纳入的7篇文献中有关两种注射法研究对象的特征、研究结果等内容用RevMan4．2软件进行分析。结果 Z径路肌内注射法和国内常规肌内注射法临床效果差异有统计学意义：前者药（血）液渗出率低（RR=0．38，95％CI为0．29～0．50，P〈0．05）、皮肤变色率低（RR=0．34，95％CI为0．22～0．52，P〈0．05）、组织变形率低（RR=0．39，95％CI为0．21～0．72，P〈0．05）、疼痛发生率低（RR=0．40，95％CI为0．33～0．50，P〈0．05）。结论 Z径路肌内注射法较常规肌内注射法所致局部不良反应的发生率低，相关并发症少，药物利用度高，适合在临床上推广应用。

Objective To analyze and compare the clinical effect of Z-track intramuscular injection and routine intramascular injection. Methods Articles on the two injection methods in China were retrieved using computer and were subjected to Meta analysis. The details of the subjects in the 7 retrieved articles and the results of the studies were reviewed and analyzed using Revman 4.2 software. Results Compared with routine intramascular injection,Z-track intramuscular injection was associated with significantly lower rates of physic liquor leakage （ RR =0.38,95% CI： 0. 29-0.50, P〈 0.05） ,of skin purpura（ RR =0.34,95% CI：0.22-0.52, P 〈0.05） ,of subcutaneous nodules （ RR =0.39,95% CI：0.21-0.72, P 〈0.05） ,and of pain（ RR =0.40,95% CI：0.33-0.50, P 〈 0.05）. Conclusion Z-track intramuscular injection is superior to the routine intramuscular injection,with less local adverse reaction and less related complications. Z-track method is worth popularizing in the clinic.