摘要
目的探讨Fractalkine（FKN）受体CX3CR1基因多态性V249I和T280M与颈动脉内-中膜增厚（IMT）的相关性。方法选取117例颈动脉IMT病人和93例无增厚对照者,通过聚合酶联反应-限制性内切酶片段长度多态性（PCR-RFLP）确定基因型。结果T280M和TM与TT的OR值为1.896,与颈动脉IMT有关（95%CI：1.015-3.542,P=0.043）,而V249I和VI与VV之间差异无显著意义（95%CI：0.531-1.600,P=0.772）。多变量Logistic回归分析显示,T280M是颈动脉IMT的独立危险因素（95%CI：1.247-8.297,P=0.016）。结论CX3CR1 T280M是颈动脉IMT的一个独立危险因素,而V249I在颈动脉粥样硬化过程中不起主要作用。
Objective To investigate the association between Fractalkine （FKN） receptor CX3CR1 Polymorphisms （V249I and T280M） and carotid artery intima-media thickness （IMT）. Methods This study aws done in 117 patients with carotid artery IMT and 93 subjects without carotid artery IMT （controls）. Polymorphic genotypes were determined by PCR-RFLP. Results The OR of T280M allele （MM and TM vs TT） was 1. 896, which was associated with carotid artery IMT （95%CI： 1.015-3.542,P=0.043）. No significant differences were observed in 1 249 allele （95%CI：0.531-1.600,P=0.772）. Multiple Logistic regression analysis revealed that the T280M allele was an independent risk factor for carotid artery IMT （95 %CI： 1. 247- 8. 297,P=0. 016）. Conclusion CX3CR1 T280M polymorphism is an independent risk factor for carotid artery IMT,and V249I does not play a major role on the progression of carotid atherosclerosis.
出处
《青岛大学医学院学报》
CAS
2008年第3期216-219,共4页
Acta Academiae Medicinae Qingdao Universitatis
