卡维地洛对心力衰竭患者心功能、血管内皮舒张功能影响

Effects of Carvedilol on Vascular Endothelium Function and Heart Function of Patients with Chronic Heart Failure

目的观察卡维地洛对充血性心力衰竭患者的临床疗效,心功能、血管内皮舒张功能的影响。方法将临床收治的74例慢性充血性心力衰竭患者随机分为卡维地洛组37例和常规组37例。常规组常规应用洋地黄、利尿剂和血管紧张素转化酶抑制剂,卡维地洛组在常规治疗基础上加用卡维地洛治疗,且卡维地洛用量在耐受情况下逐渐加大用量。共治疗6个月后观察患者的心功能、肱动脉内皮舒张功能。结果卡维地洛组较常规组心功能与肱动脉内皮舒张功能明显改善(P<0.01)。卡维地洛组在耐受剂量范围内未见明显不良反应和肝肾功能损害。结论合用卡维地洛有助提高心衰常规药物治疗效果。

Objective To observe the effects of carvedilol on vascular endothelium function and heart function of patients with chronic heart failure （CHF）. Methods 74 cases with CHF were divided randomly into the normal group （n =37） and the carvedilol group （n = 37）, Digitalis, diuretic and angiotensinconverting enzyme （ACE） were taken into normal group, while carvedilol were taken into the carvedilol group; the close of carvedilol was gradually increased within the tolerance range. The vascular endothelium function and heart function were observed after six - month period, Results The vascular endothelium function and heart function of the carvedilol group were improved remarkably compared with that of the normal group, There appeared no side effect and no impairment of liver and renal function in carvedilol group. Conclusions Applying carvedilol could enhance the curative effect of CHF patients.