烷基链封端的两亲性超支化聚缩水甘油的合成及自组装

Synthesis and Self-Assembly of Alkyl Esterified Hyperbranched Polyglycerols

通过阳离子开环聚合和端基改性的方法合成了以亲水性超支化聚缩水甘油为核和疏水性十六烷基链为臂的两亲性超支化多臂共聚物（HPG-g-C16），研究了十六烷基疏水臂的接枝率对该两亲性聚合物在溶剂中自组装行为的影响。结果表明：接枝率45％以上的HPG-g-C16在四氢呋喃（THF）中以单分子胶束的形式存在，在THF与水的混合溶剂中会自组装形成尺寸为1～10μm的巨型囊泡，而接枝率为15％的HPG-g-C16能直接在水中自组装形成球形胶束。

A series of pamitoyl chloride grafted hyperbranched polyglycerols were synthesized through cationic ring-opening polymerization and end group modification, with the purpose of investigating the self-assembly behavior of polymers with a hydrophilic core and hydrophobic arms. The obtained grafted copolymer of HPG-g-C16 possesses a hydrophilic hyperbranched polyether core and many hydrophobic alkyl arms, which shows interesting self-assemble behaviors in THF and water. Result shows that the polymers with alkyl substitution degree higher than 45%can form unimolecular micelles in THF and will further assemble into giant vesicles around 1～10 μm in THF/water mixed solvent. However, the HPG-g-C16 with a low alkyl substitution degree of 15% can directly assemble into polymer micelles in water.