期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

白细胞介素18研究进展 被引量：2

Advances in the Study on Interleukin-18
下载PDF
导出
摘要 白细胞介素18具有多种生物学活性,能诱导Th1细胞和自然杀伤细胞产生干扰素γ,促进细胞毒T淋巴细胞和自然杀伤细胞表达FasL,增强Fas-FasL介导的细胞毒作用,有较强的抗病毒作用,并与脑损伤的免疫病理机制有一定的关系。 Interleukin-18 （IL-18） has a lot of biological activities, which can induce Th 1 cells and natural ceils to produce IFN-γ, up-regulate the levels of FasL expressed by cytotoxic T ceil and natural ceils, enhance the cytotoxicity of CTL and NK mediated by Fas-FasL,and present antivirus effect stongly. In addition, IL-18 has been demonstrated to be associated with immunopathologic mechanism in brain lesions.
作者 刘培华 范良军
机构地区 湖南省石门县人民医院神经内科
出处 《医学综述》 2008年第13期1944-1946,共3页 Medical Recapitulate
关键词 白细胞介素18 抗病毒 脑损伤 Interleukin-18 Antivirus Brain lesions
分类号 R392.7 [医药卫生—免疫学]
  • 相关文献

参考文献22

  • 1Biet F, Locht C, Kremer L. Immunoregulatory functions of interleukin-18 and its role in defense agaist bacterial pathogens[J]. J Mol Med, 2002,80 (3) : 147 -162.
  • 2Skurk T, Kolb H, Muller-Scholze S, et al. The proatherogenic cytokine interleukin-18 is secreted by human adipocytes [ J ]. Eur J Endocrinol,2005,152 (6) :863-868.
  • 3Sugama S, Cho BP, Baker H ,et al. Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS[ J]. Brain Res,2002,958( 1 ) :1-9.
  • 4Thompson SR,Humphries SE. Interleukin-18 genetics and inflammatory disease susceptibility [ J ]. Genes Immunol, 2007,8 ( 2 ) : 91-99.
  • 5Culhane AC,Hall MD,Rothwell NJ,et al. Cloning of rat brain interleukin-18 CDNA[J]. Mol Psychiatry,1998,3(4) :362-366.
  • 6Wang N, Sugama S, Conti B, et al. Interleukin-18 mRNA expression in the rat pituitary gland [ J ]. J Neuroimmunol, 2006, 173 ( 1/2 ) : 117-125.
  • 7Fukushima K, Ikehara Y, Yamashita K. Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production [ J ]. J Biol Chem, 2005,280 ( 18 ) : 18056-18062.
  • 8Andre R, Wheeler RD, Collins PD, et al. Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain [ J ]. J Neuroimmunol,2003,145 ( 1/2 ) :40-45.
  • 9Suzuki N, Chen NJ, Millar DG, et al. IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Thl cell responses [ J ]. J Immunol,2003,170 ( 8 ) :4031-4035.
  • 10Chandrasekar B, Mummidi S, Mahimainathan L, et al. Interleukin- 18oinduced human coronary artery smooth muscle cell migration is dependent on NF-kappaB and AP-1-mediated matrix metalloprotei- nase-9 expression and is inhibited by atorvastatin [ J ]. J Biol Chem,2006,281 (22) :15099-15109.

二级参考文献5

  • 1Zwijnenburg PJ,Van der poll J,Florquin S,et al.Interleukine.18 gene.deficient mice show enhanced defense and reduced inflammation during pneumococcal meningitis[J].J Neuroimmunol,2003,138 (1):31-37.
  • 2Yatsiv I,Morganti Kossmann MC,Perez D,et al.Elevated intracranial IL.18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL.18.binding protein after experimental closed head injury[J].J Cereb Blood Flow Metab,2002,22(8):971-978.
  • 3Ildan F,Polat S,Oner A,et al.Effects of naloxone on sodium.and potassium.activated and magnesium.dependent adenosine.5'.triphosp.hatase activity and lipid peroxidation and early ultrastructural findings after experimental spinal cord injury[J].Neurosurgery,1995,36(4):797-805.
  • 4Liao SL,Chen WY,Raung SL,et al.Neuroprotection of naloxone against ischemic injury in rats:role of mu receptor antagonism[J].Neurosci Lett,2003,345(3):169-172.
  • 5Liu B,Du L,Hong JS.Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation[J].J Pharmacol Exp Ther,2000,293(2):607-617.

共引文献12

同被引文献18

  • 1周双海,赵东升,磨美兰,郭鑫,杨汉春.猪圆环病毒2型感染对猪肺泡巨噬细胞生物学活性的影响[J].中国兽医科技,2005,35(10):775-778. 被引量：7
  • 2周双海,杨汉春,郭鑫,司兴奎,赵东升.PCV2感染对猪MCP-1和IL-8 mRNA表达的影响[J].中国兽医科学,2006,36(6):468-471. 被引量：8
  • 3Skurk T, Kolb H, Muller Scholze S, et al. The proatherogenic cytokine interleukin-18 is secreted by human adipocytes [J]. EurJ Endocrinol, 2005, 152 (6): 863 868.
  • 4Biet F, Locht C, Kremer L. Immunoregulatory functions of interleukin-18 and its role in defense against bacterial pathogens[J]. J MolMed, 2002, 80 (3): 147-162.
  • 5Gracie J A, Robertson S E, Me Innes I B. Interleukin-18[J]. J Leukoc Biol, 2003, 73 (2):213-224.
  • 6Reddy J, Bruce N, Wilkie N. Quantification of porcine cytokine and beta 2-microglobulin mRNA expression by reverse transcription polymerase chain reaction[J]. Vet Immunol Immunopathol, 2000, 233: 83-93.
  • 7John S B, Sivadasan K, Barry T. Rouse limitation and modifications of quantitative polymerase chain reactionl[J]. J Immunol Method, 1993, 65: 207-216.
  • 8Nakanishi K, Yoshimoto T, Tsutsui H, et al. Interleukin 18 regulates both Thl and Th2 responses[J]. Annu Rev Immunol, 2001,19: 423-474.
  • 9Domeika K M, Berg M L, Alto G V. Porcine interleukin-12 fusion protein and interleukin-18 in combination induce Interferon-7 production in porcine natural killer and T cells[J]. Vet Immunol Immunopathol, 2002, 86: 12-21.
  • 10Kimura K, Kakimi K, Wieland S, et al. Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice [J]. JVirol, 2002,76, 10702-10707.

引证文献2

二级引证文献11

医学综述
2008年 第13期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部