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IL-13Rα2、VEGF和PTEN在人脑胶质瘤中的研究进展 被引量：2

Progress in Study on IL-13Rα2,VEGF and PTEN in Malignant Gliomas
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摘要 胶质瘤是中枢神经系统发生率最高的恶性肿瘤,其治疗仍然是一大难题。近年来,对脑胶质瘤发病的相关分子机制和凋亡机制已进行了广泛而深入的研究,为进一步探讨胶质瘤的分子病因、分子分型、恶性进展、基因治疗及预后评估奠定了基础,尤其是对白细胞介素13受体α2(IL-13Rα2)、血管内皮生长因子(VEGF)及人10号染色体上缺失的磷酸酶和张力蛋白类似物(PTEN)的深入研究。本文总结了IL-13Rα2、VEGF和PTEN的研究进展及其临床意义。 The gliomas is a malignant tumors in central nervous system with the highest incidence, its therapy is still a difficult problem. There had been wide and deep studies on molecular mechanism and apoptosis of gliomas, which involved the molecular etiology malignant progression, molecular subtyping, gene therapy, and prognosis of gliomas, especially in IL-13 Rα 2, VEGF and PTEN. This article summarized the progress in IL-13Rα2 ,VEGF and PTEN ,and their clinical significances.
作者 涂明 郑伟明
机构地区 温州医学院 温州医学院附属第一医院神经外科
出处 《医学综述》 2008年第13期1966-1969,共4页 Medical Recapitulate
关键词 胶质瘤 白介素13受体α2 血管内皮生长因子 第10号染色体缺失且与张力蛋白同源物磷酸脂酶基因 Glioma Intedeukin-13 receptor α2 Vascular endothelial growth factor Phosphatase and tensin homolog deleted on chromosome 10
分类号 R739.4 [医药卫生—肿瘤]
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参考文献20

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二级参考文献14

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共引文献13

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二级引证文献9

医学综述
2008年 第13期

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