孕产妇幽门螺旋杆菌感染及其与病理妊娠的关系

The relationship between H pylori infection in pregnant woman and pathologic pregnancy

目的:探讨孕产妇幽门螺旋杆菌感染情况及其与病理妊娠的关系。方法:随机选取门诊和住院的孕产妇,用胶体金层析法幽门螺旋杆菌抗原检测试剂盒检测孕产妇粪便中幽门螺旋杆菌抗原(HpSA),对孕产妇归类分组,并计算出幽门螺旋杆菌感染率。结果:共对3620例孕产妇进行了粪便幽门螺旋杆菌抗原检测。正常妊娠孕产妇2 578例中HpSA+106例,幽门螺旋杆菌感染率为4.11%,病理性妊娠孕产妇1 042例中HpSA+50例,感染率为4.80%,略高于正常孕产妇,但统计学上无显著差异(P>0.05)。其中,妊娠剧吐、流产、死胎等早中期病理妊娠孕产妇幽门螺旋杆菌的HpSA+率为8.52%,显著高于正常孕产妇组和晚期病理妊娠组(P<0.01);在所有病理妊娠中,又以胎儿生长受限和妊娠剧吐孕产妇感染率最高,HpSA+率分别为27.3%和17.2%,显著高于正常孕产妇组和其他病理妊娠组(P<0.01)。结论:幽门螺旋杆菌感染与早中期病理妊娠,尤其是妊娠剧吐和胎儿生长受限有一定的关系,可能是诱发早中期病理妊娠和胎儿生长受限的因素之一。

Objective： To analyze the Helicobacter pylori （ H. pylori） infection in pregnant women and the relationship with pathologic pregnancy. Methods： The stool antigen of H. pylori （HpSA） in feces of random gravid from out - patient clinic and in hospital were detected by Gold - Immunochromatographic Assay. Results： The HpSA in feces of 3620 pregnant women were investigated, HpSA positive rate of normal pregnant women was 4. 11% ; HpSA positive rate of pregnant women with pathologic pregnancy was 4. 80%, it was not significandy higher than that of normal pregnant women （P 〉 0. 05 ） . Especially, HpSA positive rate of pregnant women with early and middle pathologic pregnancy was 8.52%, it was significantly higher than that of pregnant women with late pathologic pregnancy （ P 〈 0. 0 1 ） . Especially, the HpSA positive rate of pregnant women with fetal growth restriction and hyperemesis gravidarum was 27.3% and 17.2% respectively, both them were significantly higher than that of pregnant women with early and late pathologic pregnancy （ P 〈 0. 0 1 ） . Conclusion： There are close relationships between H. pylori infection and early or middle pathologic pregnancy, especially fetal growth restriction and hyperemesis gravidarum of them.