针刺对慢性应激抑郁模型大鼠行为学的影响

Effect of acupuncture on behavior in the chronic stressed depression rats

目的:探讨针刺百会、太冲穴对慢性应激抑郁模型大鼠行为学的影响。方法:将35只雄性Wistar大鼠随机分为正常对照组、抑郁模型组、生理盐水组、针刺治疗组和阿米替林组,每组7只。采用针刺百会、太冲穴对慢性应激抑郁模型大鼠行为学变化进行了观察研究。结果:造模21天后各组大鼠的水平运动和垂直运动得分均较正常组明显减少,体重增加减慢,糖水消耗量降低;而针刺治疗组与阿米替林组均可显著增加大鼠水平运动和垂直运动得分,使体重增加,糖水消耗量增加,改善大鼠的抑郁状态,各治疗组间差异不显著。结论:针刺可以改善慢性应激抑郁模型大鼠的抑郁状态。

Objective:In order to investigate the effects of acupuncture at points baihui and taichong on behavior in the animal model of chronic stressed depression.Methods:35 male wistar rats were randomly allocated to five groups as follows: control group、depression model group、saline group、acupuncture group and amitriptyline group.The behavior of rats were investigated after acupuncture treatments.Results:Compared with control group,the duplicated model rats' crossing and reaching movements decreased significantly;the weight increase slowly and the sucrose preference decreased;The acupuncture group and amitriptyline group can increase the depressed rats crossing and reaching movements|、the weight and the sucrose preference significantly.There is no marked difference between the treatment groups and the control group.Conclusion: Acupuncture treatment can modify the behavior of depressed rats.