122例恶性梗阻性黄疸患者介入引流术后总胆汁酸检测的意义

Significance of Total Bile Acid Detection after Interventional Drainage in 122 Cases with Malignant Obstructive Jaundice

[目的]观察恶性梗阻性黄疸患者于经皮肝穿刺胆道造影及引流术(PTCD)术后血清总胆汁酸(TBA)、总胆红素(TBL)及直接胆红素(DBL)的变化。[方法]122例恶性梗阻性黄疸患者PTCD术前1d及术后第3d至4周内作TBA、TBL、DBL检测。[结果]PTCD术前TBA(131.8±76.6μmol/L)与TBL(416.0±127.5μmol/L)、DBL(300.4±86.9μmol/L)有良好相关性(r值:0.358、0.379,P<0.05);术后3dTBA下降明显(15.9±22.6μmol/L),与术前(131.8±76.6μmol/L)比较有显著性差异(P<0.01)。[结论]血TBA可作为检验PTCD术后黄疸引流是否有效的可靠指标。

[Purpose] To study the alteration of serum total bile acid（TBA）, total bilirubin（TBL） and direct bilirubin（DBL） after percutaneous transhepatic cholangiography and drainage（PTCD） for malignant obstructive jaundice patients. [Methods ] TBA,TBL and DBL were detected 1 day before and 3 days to 4 weeks after FFCD. [Results] TBA （131.8 ±76.6μmol/L） closely correlated with TBL （416.0±217.5μmol/L） and DBL （300.4±86.9μmol/L） before FFCD（r：0.358,0.379,P〈0.05）. TBA decreased significantly at 3d after FFCD （15.9±22.6μmol/L）, with significant, descending rate of TBA difference compared with that before PTCD（131.8±76.6μmol/L）（P〈0.01）. [Conclusion] TBA can be used as a reliable indicator to test whether jaundice draining is effective.