儿童急性淋巴细胞性白血病侵袭性真菌感染探讨

Invasive fungal infections in children with acute lymphoblastic leukemia

目的探讨儿童急性淋巴细胞性白血病发生侵袭性真菌感染的相关因素及临床表现。方法对儿童急性淋巴细胞性白血病临床资料进行回顾性分析。结果282例中发生侵袭性真菌感染89例,感染率31.6%。发热、咳嗽咳痰、口腔粘膜白斑是最常见的临床表现。结论急性淋巴细胞性白血病患儿侵袭性真菌感染发生率呈上升趋势,强烈化疗阶段更易并发感染。分层诊断是早期发现及控制感染的有效方法。

Objective To investigate the clinical manifestations and relative factors of invasive fungal infections in children with acute lymphoblastic leukemia（ALL）. Methods Retrospective analysis was used to study the clinical materials of 282 children with ALL. Results 89 cases （times） of invasive fungal infections were found in 282 patients with an infection rate of 31.6%. The most common clinical manifestations were fever, cough, expectoration and oral mucosal leucoplakia. Conclusion The incidence of invasive fungal infections increases in patients with ALL. Concurrent infection is more easily to occur during intensive chemotherapy. Stratified diagnosis is an effective method for the early detection and control of the infection.