母乳性黄疸患儿胆汁胆红素和总胆汁酸测定的临床意义

Clinical significance of detecting the total bilirubin and total bile acid of breast-feeding jaundice infants

目的探讨母乳性黄疸患儿胆汁中胆红素和总胆汁酸浓度及临床意义。方法应用婴儿十二指肠引流管和引流技术收集12例母乳性黄疸患儿干预前后胆汁,检测胆汁中总胆红素(TB)、直接胆红素(DB)和胆汁酸(TBA)浓度,并与血清中TB、DB、TBA对照分析。结果12例干预前母乳性黄疸患儿胆汁中TB、DB和TBA分别为(172.1±98.2)μmol/L、(105.6±60.0)μmol/L、(561.2±104.2)μmol/L;干预后12例胆汁TB、DB和TBA分别为(180.2±88.6)μmol/L、(106.8±70.0)μmol/L、(580.3±84.2)μmol/L,干预前后无显著性差异(P>0.05)。结论母乳性黄疸患儿胆汁中TB、DB和TBA浓度正常,提示母乳性黄疸患儿胆红素和胆汁酸摄取、转运、排泄功能正常。

Objective To study the concentration of total bilirubin（TB） and total bile acid （TBA） in the bile of breastfeeding jaundice infants and the significance of the alternation between prior and post-treatment. Methods The duodenal fluids were collected by the special duodenal drainage-tube from 12 infants who were suffered from breast-feeding jaundice and 12 infants completely cured. The concentration of TB, DB and TBA in bile and in serum were detected and compared. Results In contrast with the dramatically decreased concentration of TB ,DB and TBA in serum of cured patients（P〈0. 05） , no significant changes of TB andTBA in jaundice infantile bile were found （P〈0. 05）. Conclusion The concentration of TB and TBA in breast-feeding jaundice infantile suggests that the functions of uptaking, transporting and excepting bilirubin and bile acid by the liver of the sick infants are normal.