摘要
以E-1,4-二溴-2-丁烯和亚磷酸三乙酯为起始物,通过Wittig-Horner反应合成化合物2,7-二甲基-2,4,6-辛三烯-1,8-二醛;然后以E-2-甲基-2-丁烯酸为起始物经过溴代、酯化合成E-2-甲基-2-丁烯酸甲酯-4-膦酸二乙酯.两化合物通过Wittig-Horner反应生成西红花酸二甲酯.西红花酸二甲酯水解得西红花酸.
In this paper we describe an efficient seven-step synthesis of crocetin through the use of in situ procedures. Firstly, crocetin-dimethylester was synthesized by the Wittig-Horner reaction with two compounds 2,7-dimethyl-2,4,6-oct-triene-l,8-dialdehyde and methyl O,O-diethylp-phosphonotiglate. Crocetindimethylester was then converted into crocetin.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2008年第12期1451-1454,共4页
Acta Chimica Sinica
基金
国家自然科学基金(No.30472064)资助项目
