弓上颅内外动脉狭窄与同型半胱氨酸的关系探讨

Investigation into Relation between Upra-arch Extra-or Intracranial Artery Stenosis and Homocysteine

目的观察弓上颅内外动脉狭窄患者血浆同型半胱氨酸(Homocysteine,Hcy)的水平,并探讨其与狭窄血管支数的关系。方法将2006年6月—2007年12月在我科住院行全脑血管造影的189例患者中资料完整的128例根据血管造影结果及头颅CT或MRI表现分为四组:脑梗死单支血管狭窄组,脑梗死多支血管狭窄组,脑梗死无血管狭窄组,非脑梗死非血管狭窄组(脑出血或蛛网膜下腔出血),测定各组血浆同型半胱氨酸的水平。结果Hcy水平:脑梗死多支血管狭窄组(35.14±14.99)>脑梗死单支血管狭窄组(22.90±8.02),脑梗死无血管狭窄组(16.64±4.39)>非脑梗死非血管狭窄组(11.69±6.35)。结论脑梗死多支血管狭窄组Hcy水平明显升高,提示Hcy水平与弓上颅内外血管狭窄密切相关,血管狭窄病变越严重,血浆Hcy水平越高。

Objective To analyze the relation between upra-arch extra-or intracranial artery stenosis and homocysteine. Methods Among 189 patients （between July 2006 and December 2007） , 128 with findings of DSA and CT or MRI were divided into four groups （ n = 32/group）, i.e. Group A （ infarction with one artery stenosis ）, Group B （ infarction with multi-artery stenosis ）, Group C （ infarction without artery stenosis）, and Group D （ non-infaretion without artery stenosis）. Results The levels of plasma homocysteine were 35.14 ± 1 4.99 in Group B, 22.90 ± 8.02 in Group A, 16.64 ± 4.39 in Group C, and 11.69 ± 6.35 in Group D, respectively. Conclusion The level of plasma homocysteine is higher in the group of infarction with multi-artery stenosis than in any of the other groups. The clinical data indicate that hyperhomocysteine is associated with the number of upra-arch extra-or intracranial artery stenosis.