药用植物来源的新药研发进展

Drug Discovery from Medicinal Plants

植物来源的天然产物药物在癌症、艾滋病和疟疾等疾病的治疗中发挥了越来越重要的作用。对热带雨林中的植物进行广泛的活性筛选,以及从可食用植物中提取起保健作用的活性成分是当前的研究热点。目前,植物来源的新药开发研究在材料的选择、高通量活性筛选以及活性成分的分离制备等方面正面临许多严峻的挑战。

Current researches in drug discovery from medicinal plants continues provide new and important leads against various pharmacological targets including cancer, AIDS and malaria. Numerous compounds from tropical rainforest plant species especially from edible plant species or plants used as dietary supplements with potential biological activity have been identified. Nowadays, numerous challenges are encountered including the procurement of plant materials, the selection and implementation of appropriate high - throughput screening bioassays, and the scale - up of active compounds.