摘要
目的研究大豆苷元(daidzein,DD)对腹主动脉缩窄大鼠靶器官脂质过氧化反应的影响。方法采用腹主动脉缩窄术制备大鼠实验模型。将大鼠随机分为假手术对照组、模型组、DD(30,60,120 mg.kg-1)治疗组。给药4周后处死大鼠,测量大鼠脑、肾、肝组织中丙二醛(MDA)含量,超氧化物歧化酶(SOD)活性以及谷胱甘肽过氧化物酶(GSH-PX)活性。结果与模型组比较,DD能使大鼠脑、肾、肝组中MDA含量显著降低,SOD及GSH-PX活性显著升高。结论腹主动脉缩窄术能引起大鼠脑、肾、肝脏异常的脂质过氧化状态,DD可以减轻脑、肾、肝脏脂质过氧化损伤作用。
Objective To study the influence of daidzein on lipid - peroxidation of target - organ in rats with abdominal aorta constriction. Methods The model rats were prepared by abdominal aorta constriction. The operated rats were divided into sham operated control group , aorta- constricted model group and three DD groups （ 30,60,120 mg· kg^- 1 ）. After four week treatment, the content of malondialdehyde（MDA）, the activities of superoxide dismutase （SOD） and glutathione peroxidase （GSH- PX ） in brain, kidney and liver of all rats were measured. Results Compared with aorta - constricted model group, DD could significantly decrease the content of MDA and increase the activities of SOD and GSH - PX respectively in brain, kidney and liver in rats. Conclusion Abdominal aorta constriction can result in peroxidation in rat, and DD can alleviate the body lesion caused by peroxidation.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2008年第6期1372-1373,共2页
Lishizhen Medicine and Materia Medica Research
基金
江西省卫生厅中医药资助项目(No.2006A66)
