摘要
目的:本研究拟比较羟基喜树碱(喜素,HCPT)联合顺铂(DDP)与顺铂联合5-氟尿嘧啶(5-Fu)治疗晚期食管癌的近期疗效及不良反应。方法:对60例经病理证实的晚期食管癌初治患者给予联合化疗,随机分为DH组或DF。每组各30例,DH组病例应用HCPT(6mg/m^2d1~3)加DDP(25mg/m^2dl~3),DF组病例应用5-Fu(750mg/m^2dl~5)加DDP(25mg/m^2dl~3),21d为一个周期。每例患者治疗少于2个周期。结果:DH组患者总有效率为46.7%,中位缓解期4.2个月;DF组患者总有效率为50.0%,中位生存期3.8个月,两组有效率比较差异无显著性。最常见的毒副反应为骨髓抑制和恶心、呕吐,DH组20.0%(6/30)出现Ⅲ~Ⅵ度白细胞下降,DF组13.3%(4/30)出现Ⅲ~Ⅳ度白细胞下降,二者比较差异无统计学意义,DH组和DF的Ⅲ+Ⅵ度恶心、呕吐反应发生率分别为33.3%和30.0%。差别无统计学意义。DH组腹泻发生率26.7%,但可耐受。结论:DH与DF方案相比,疗效相似,不良反应虽有所不同,但毒性可以耐受,是对晚期食管癌有效的化疗方案之一。
Objective: To compare the response rate and the side effects of the regimen DH (DDP , HCPT) with DF ( DDP, 5 - Fu ) in the treament of advanced esophageal cancer. Methods: A total of 60 cases with advanced esophageal entered this trial. The patients were randomly divided into trial group and control group , and received chemotherapy of DH regimen or DF regimen respectively . Each patient received at least 2cycles of chemotherapy. Results: The overall response rate was 46.7% in the DH group and 50.0% in the DF group , the difference between the two groups did not reach statistical significance ( P 〉 0. 05 ) . The major effects were leucopenia,nause in the two groups , the incidence of diarrhea was significantly higer in DH group than in DF group( 26.7% VS 3.3%, P 〈 0. 05 ), but the toxicity was tolerable. Conclusion: Both DH and DF regimens are effective for advanced esophageal cancer and have no significant difference , the side effect of the two regimens are different but all adverse reactions are tolerable.
出处
《河北医学》
CAS
2008年第7期798-801,共4页
Hebei Medicine
关键词
羟基喜树碱
顺铂
晚期食管癌
联合化疗
HCPT
Cisplatin
Advanced esophageal cancer
Combination chemotherapy