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LADA患者自身抗体检测的临床意义 被引量：3

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摘要 糖尿病（diabetes mellitus）是以高血糖为特征、以糖代谢紊乱为主要表现的慢性复杂的代谢性疾病。1型糖尿病（type 1diabetes mellitus，T1DM）具有胰岛B细胞产生胰岛素功能受损的特征，是一种免疫介导的疾病。成人迟发性自身免疫性糖尿病（LA—DA）是一种特殊类型的1型糖尿病（T1DM），其临床表现与2型糖尿病（T2DM）相似，但发病机制却是由于免疫介导的胰岛细胞炎性破坏，可导致胰岛功能迅速恶化，
作者 张利永 王亚龙 刘永会
机构地区 中国人民解放军第 河北大学医学部 围场县医院脑外科
出处 《河北职工医学院学报》 2008年第3期31-33,共3页 Journal of Hebei Medical College for Continuing Education
关键词 糖尿病 胰岛细胞抗体 检测
分类号 R-332 [医药卫生]
  • 相关文献

参考文献13

  • 1Savola K,Sabbah E,Kulmala P,et al. Autoantibodies associated with type 1 diabetes mellitus persist after diagnosis in children [J]. Diabetologia, 1998, 41( 11 ) : 1293-1297.
  • 2Hoppu S, Harkonen T, Ronkainen MS, et al. IA-2 antibody types and epitope specificity during the prediabetic process in children with HLA-conferred susceptibility to type 1 diabetes [J ]. Clin Exp Immul, 2006,144( 1 ) : 59-66.
  • 3Schem idli RS, Colm an PG, Bonifacio E, et al. High level of concordance between assays for glutamic acid decarboxylase antibodies. The first international glutam acid decarboxylase antibody workshop [J ]. Diabetes, 1994,43 : 1 005.
  • 4Irvine,W. J. , C. J. McCallum, R. S. Gray,et al. Pancreatic islet cell antibodies in diabet es mellitus correlated with duration and type of diabetes,coexistant autoimm une disease and HLA type [ J ]. Diabetes, 26: 138-147.
  • 5Riley,W. J. , N. K. MacLaren, J. H. Silverstein (1988). The predictability of insulin-dependent diabetes mellitus [J]. Adv. Pediatr., 35 : 1672187.
  • 6Pozzili P. Mario UD. autoimmune diabetes not requiring insulin at diabetes (latent autoimmune diabetes of the adult) [ J ]. Diabetes Care, 2001,24(8 ) : 1460-1467.
  • 7Schranz DB,Bekris L,Landin-Olsson M,et al. Newly diagnosed latent autoimmune diabetes in patients presenting with type 2 diabetes[J]. Metabolism,2001,50(9):1008-1013.
  • 8Durinovic-Bello I, Hummel M, Ziegler AG,et al. Cellular immune respons to diverse islet cell antigens in IDDM[J]. Diabetes, 1996,45 : 795.
  • 9胡白瑛,周智广,颜湘,彭健.磺脲类降糖药继发失效患者中成人隐匿性自身免疫糖尿病的患病率调查[J].中国糖尿病杂志,2003,11(3):168-171. 被引量：9
  • 10Rowley MJ, Mackay IR, Chen QY, et al. Antibodies to glutamic acid decarboylase discriminate major types of diabetes mellitus [ J ]. diabetes, 1992,41 : 548.

二级参考文献6

  • 1[1]Bruce R,Zimmerman MD.Sulfonylureas.Endocrin Metab Clin North Am,1997,26:511-522.
  • 2[2]Matthews DR,Cull CA,Stratton IM,et al.UKPDS 26: Sulfonylurea failure in non-insulin-dependent diabetic patients over six years. Diabet Med, 1998,15:297-303.
  • 3[3]Fukui M, Nakano k, Maruya E, et al. Diagnostic significance of antibodies to glutamic acid decarboxylase in Japanese diabetic patients with secondary oral hypoglycaemic agents failure. Clin Immuno Immunopath,1997,85:182-186.
  • 4[4]Fukui M, Nakano k, Shigeta H, et al. Antibodies to glutamic acid decarboxylase in Japanese diabetic patients with secondary oral hypoglycaemic therapy. Diabet Med, 1997,14:148-152.
  • 5[5]Rattarasarn C, Diosdado MA, Soonthornpan S, et al. Glutamic Acid Decarboxylase Antibodies in Non-insulin-dependent Diabetes patients with secondary sulphonylurea failure in Thailand. Diabet Res Clin Pract, 1997,37:193-197.
  • 6[6]Isomaa B, Almgren P, Henricsson M,et al. Chronic complications in patients with slowly progressing autoimmune type 1 diabetes (LADA). Diabetes Care, 1999,22:1347-1353.

共引文献167

同被引文献34

引证文献3

二级引证文献12

河北职工医学院学报
2008年 第3期

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