摘要
目的探讨胆管癌组织中MMP-9和nm23-H1的表达水平,了解胆管癌组织中MMP-9和nm23-H1表达的相关性及其与胆管癌浸润转移的关系。方法采用免疫组织化学法(PV-9000)检测60例胆管癌(35例浸润转移组,25例无浸润转移组)MMP-9和nm23-H1的表达。结果有浸润转移的35例胆管癌标本中,MMP-9和nm23-H1表达的阳性率分别为71.4%(25/35)和25.7%(9/35);无浸润转移的25例胆管癌标本中,MMP-9和nm23-H1表达的阳性率分别为40.0%(10/25),和60.0%(15/25);MMP-9的表达与胆管癌浸润转移倾向呈正相关性(P<0.05),nm23-H1的表达与胆管癌的浸润转移倾向呈负相关性(P<0.01)。而MMP-9与nm23-H1的表达呈负相关性(P<0.01)。结论MMP-9及nm23-H1的表达可能作为胆管癌预后及转移潜能判断的指标。
Objective To detect the expression of MMP-9 and nm23-H1 in cholangiocarcinoma,and to explore their correlation to invasion and metastasis in cholangiocarcinoma. Methods The expression of MMP-9 and nm23-H1 were detected with immunohistochemistry(PV-9000) in 35 samples with invasion and metastasis and 25 samples without invasion and metastasis. Results In invasion and metastasis samples,the positive rates of MMP-9 and nm23-H1 were 71.4%(25/35) and 25.7%(9/35),respectively.In samples without invasion and metastasis,the positive rates were 40.0%(10/25) and 60.0%(15/25),respectively.The expression of MMP-9 was positively related to invasion and metastasis in cholangiocarcinoma(P〈0.05),but negatively related to nm23-H1 expression(P〈0.01).The expression of nm23-H1 was negatively related to invasion and metastasis in cholangiocarcinoma(P〈0.01). Conclusion MMP-9 and nm23-H1 may be useful diagnostic parameters for invasion and metastasis in cholangiocarcinoma.
出处
《山西医科大学学报》
CAS
2008年第6期570-572,共3页
Journal of Shanxi Medical University