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神经胶质-免疫机制在疼痛中的作用

Glia-immunity Interactions Underlying Mechanisms of Pain (review)
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摘要 疼痛产生和维持的机制研究一直局限于神经元及由此形成的网络,对组成神经系统的另一类细胞——神经胶质细胞关注甚少。神经胶质细胞在疼痛机制中的作用,是今后疼痛研究的新方向。作者通过探讨神经胶质-免疫机制在神经病理痛发生和维持中的作用,希望为今后镇痛药物研究提供新的靶点。 Pain is classically viewed as being mediated solely by neurons. This view is dramatically changing by new research that spinal cord glial cells amplify pain. Recognition that glial activation is a powerful driving force for exaggerated pain opens up new ways to approach effective clinical pain control. The authors reviewed spinal cord glial cells and cytokines as key players in the crea tion and maintenance of neuropathic pain.
作者 程涓 张策
机构地区 北京中医药大学附属北京东直门医院病理科 山西医科大学生理学教研室
出处 《中国康复理论与实践》 CSCD 2008年第6期501-503,共3页 Chinese Journal of Rehabilitation Theory and Practice
基金 国家重点基础研究发展计划(973计划)(No2007CB512503)
关键词 疼痛 神经胶质细胞 免疫 pain glial cell immunity
分类号 R441.1 [医药卫生—诊断学]
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参考文献24

  • 1钟代星,纪楠,王亚云,武胜昔,李云庆.脊髓胶质细胞在痛信息产生和传递过程中的作用[J].生理科学进展,2003,34(4):353-355. 被引量：8
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二级参考文献19

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中国康复理论与实践
2008年 第6期

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