摘要
目的探讨2型糖尿病大鼠p75基因表达与脑细胞凋亡的关系。方法选取2型糖尿病大鼠及正常对照组大鼠各10只,采用RT-PCR法检测脑组织p75基因mRNA表达,琼脂糖凝胶电泳检测细胞凋亡。结果2型糖尿病大鼠P75基因mRNA表达上调,且脑组织细胞凋亡明显增加。结论2型糖尿病大鼠脑组织细胞凋亡增加,与p75基因表达呈正相关。
Objective To study the relationship between expression of p75 gene and apoptosis of cerebrum cells in type 2 diabetic rats. Methods Ten type 2 diabetic rats and ten natural rats were used to test the expression of brain p75 mRNA by RT-PCR technique, and the apoptosis of cerebrum cells was measured by agarose gel electrophoresis （AGA）. Results The expression of brain p75 mRNA and apoptosis of cerebrum cells in type 2 diabetic rats were higher than that of the natural group. Conclusion The apoptosis of cerebrum cells in type 2 diabetic rats increases, and it is positively correlated with the expression of brain p75 gene mRNA.
出处
《中国康复理论与实践》
CSCD
2008年第6期533-534,共2页
Chinese Journal of Rehabilitation Theory and Practice
