酒精性肝硬化患者细胞因子改变及其临床意义

Monitoring the Change of Serum Cytokine Levels in Alcoholic Liver Cirrhosis and Its Clinical Significance

目的:探讨细胞因子IL-6、IL-8、TNF-α、IL-10在酒精性肝硬化发病机制中的作用。方法:对酒精性肝硬化代偿期和失代偿期患者及健康者用放射免疫分析法检测细胞因子的含量,并进行分析。结果:酒精性肝硬化代偿期患者IL-6升高,差异有显著性(P<0.01),IL-8、TNF-α略升高,差异无显著性(P>0.05)。IL-10下降,差异有显著性(P<0.05),酒精性肝硬化失代偿期患者IL-10无明显变化,差异无显著性(P>0.05),IL-6、IL-8、TNF-α均升高,差异有显著性(P<0.01)。结论:酒精性肝硬化患者随着病情加重,细胞因子IL-6、IL-8、TNF-α逐渐升高,细胞因子IL-10无明显改变,对酒精性肝硬化患者进行细胞因子检测,对疾病的诊断及治疗有一定的指导作用。

Objective ： To study the relationship between the change of serum cytokine levels and alcoholic liver cirrhosis. Methods ： Monitoring the change of scrum cytokine levels in compensated and decompensated alcoholic liver cirrhosis and healthy people by radioimmunoassay. Results ： Compensated alcoholic cirrhosis was characterized by increased IL - 6 and decreased IL - 10, TNF - α, IL -8 were comparable to those found in controls. Decompensated alcoholic liver cirrhosis was characterized by increased IL -6 ,TNF - α, IL -8 , IL - 10 levels was similar to those found in controls. Conclusion： Monitoring the change of seruro cytokine levels in compensated and decompensated alcoholic liver cirrhosis was helpful to the diagnosis and treatment of the disease.