米索前列醇联合利多卡因在钳刮术中的镇痛作用

Analgesia Effect of Misoprostol and Lidocaine in Scraping

目的:探讨初孕钳刮术前联合应用米索前列醇和利多卡因的镇痛效果。方法:将孕10～14周的健康初孕妇100例随机分为2组,每组各50例,Ⅰ组:米索前列醇组,Ⅱ组:米索前列醇+利多卡因组。两组受术者均术前3h阴道后穹隆放置米索前列醇400μg,Ⅱ组受术者术中同时于宫颈4点和10点处各缓慢注射2%利多卡因2ml,观察各组的宫口松驰度、镇痛效果和人工流产综合征的发生率。结果:两组在宫口松驰度、镇痛效果和人工流产综合征的发生率上差异均存在显著性(P均<0.05)。结论:初孕钳刮术前联合应用米索前列醇和利多卡因能减轻手术引起的疼痛,预防人工流产综合征的发生,在临床应用中收到满意的效果。

Objective：To investigate the analgesia effect of misoprostol combined with lidocaine before scraping in unigravida. Methods： One hundred healthy unigravidas requesting legal termination of pregnancy between 10 and 14 weeks of gestation were randomly allocated into 2 groups. Group Ⅰ ： misoprostol group; Group Ⅱ ： misoprostol combined with lidocaine group. In both groups, 400μg of misoprostol 3 hours pre - operation was placed to posterior fornix. In Group Ⅱ , cervix injected 4 ml of 2% lidocaine 3 min before operation. The degree of cervical relaxing, analgesic effect and artificial abortion syndrome were observed. Results： There were significantly statistical differences in the rate of cervical relaxing, analgesic effect and artificial abortion syndrome between two groups （P 〈 0. 05 ）. Conclusion： The use of nfisoprostol combined with lidocaine before scraping in unigravida can relieve the pain caused by operation, and cut down the rate of artificial abortion syndrome. It is a safe and effective way for clinical applying.