加替沙星和左氧氟沙星的费用效果评价

Cost Effectiveness Analysis on Gatifloxacin and Levofloxacin

目的:通过调查收集样本医院加替沙星和左氧氟沙星临床疗效、不良反应情况及相应的费用,并结合北京市二级以上医院各类喹诺酮药物销售量和单价,对加替沙星和左氧氟沙星进行费用-效果比较分析,为管理层提供相关决策依据和相应的政策建议。方法:通过收集资料、现场问卷调查和访谈,进行定量和定性调查,运用卫生经济学投入产出的分析方法进行评价分析。结果:(1)与左氧氟沙星相比,加替沙星的临床疗效,无论从安全治愈率,还是从较安全治愈率和次安全治愈率的角度看,两者的差异均无统计意义。而其不良反应率高于左氧氟沙星,且差异具有统计意义。(2)加替沙星的例均药品治疗费和不良反应处置费(332.96元)是左氧氟沙星(152.77元)的2.18倍。(3)从单纯经济性、安全-经济性。以及有效-安全-经济性(三性结合)的角度,左氧氟沙星比加替沙星治疗具有明显的经济性。结论:我们对两药治疗的费用效果分析结果提示,与加替沙星相比.左氧氟沙星更均有以较低投入获得较高产出的特点。

Objective：This study is to preliminarily describe the clinical effectiveness and treatment expenses of Gatifloxaein and Levofloxacin in sample hospitals, and give a cost effectiveness analysis combining with the sales volume and price of Quinolones drugs in the second - grade hospitals and above in Beijing in order to provide data support to decision makers on the relative decision. Methods： The data for the cost and effectiveness of Gatifloxacin and Levofloxaein were collected through the subject interview and questionnaire survey and analyzed by the method of health economics. Results： （1）Thc difference of clinical effectiveness between Gatifloxacin and Levofloxaein is not statistical significant whether from the view of safe - cure rate excluding adverse reaction, safe - cure rate including mild and moderate adverse reaction or safe - cure rate including different severity of adverse reaction. But the difference of the adverse rate between Gatifloxacin and Levofloxacin is statistical significant. （2） The expense of Gatifloxacin including drug treatment and adverse reaction per capita is 332. 96RMB and is 2. 18 times of Levofloxacin. （3）From the view of economy - only, safe - economy, effective - safe - economy, the cost effectiveness ratio of Levofloxacin is higher than that of Gatifloxacin. Conclusion： The results of cost effectiveness analysis show that Levofloxaein has the characteristics for gaining more outcomes at less cost than that of Gatifloxacin.