西酞普兰与马普替林治疗脑卒中后焦虑障碍的对照研究

A comparative study of citalopram in the treatment of post-stroke anxiety disorder

目的:比较西酞普兰与马普替林治疗脑卒中后焦虑障碍的疗效及安全性。方法:将68例患者随机分为两组,分别用西酞普兰和马普替林治疗,疗程6周。采用汉密尔顿焦虑量表(HAMA)、临床疗效总评量表(CGI-SI)评定临床疗效,副反应量表(TESS)评定副反应。结果:两组总体疗效相当(P>0.05),但两组治疗前后HAMA总分比较有显著性差异(P<0.01);西酞普兰组起效较快,副反应较少,嗜睡、口干、便秘、视物模糊及心电图异常等副反应的发生率低于马普替林组。结论:西酞普兰是治疗脑卒中后焦虑障碍的理想药物。

Objective： To compare the efficacy and safety of citalopram and maprotiline in the treatment of anxiety. Methods： A total of 68 patients who metthe criteria of CCMD- 3 for post - stroke anxiety were divided into two groups randomly, The two groups were treated with citalopram and maprotiline respectively for six weeks. The efficacy was measured with Hamiltion Anxiety Scale （HAMA） and Clinical Global Impression（CGI）, The side effects were assessed by the Treatment Emergent Symptom Scale （TESS）. Results： There was no significant difference in global efficacy between the two groups（ P 〈 0. 05） ; There were significant differences between the scores of HAM A and CGI before and after treatment in each group （ P 〈 0.01）. Citalopram took effect quicker and had less side effects, such as sleep, thirsty, constipation, blurred vision and abnormal ECG than maprotiline. Condusion： Citalopram is an effective anxiolytic the treatment of post- stroke anxiety disorder.