IL-1B-511基因多态性及幽门螺旋杆菌感染与胃癌的关系研究

The Rearch on the Relationship between IL 1B 511 Gene Polymorphism and HP Infection and Stomach Carcinoma

目的通过比较胃癌患者与匹配人群的幽门螺旋杆菌(Hp)感染率和IL-1B-511基因多态性,探讨IL-1B-511基因多态性是否增加Hp感染后胃癌发生的危险性。方法采用聚合酶链反应-限制性片段长度多态性(RFLP)分析法,检测84例胃癌患者以及与这些患者性别、年龄匹配的84例对照人群的IL-1B-511基因多态性,并采用酶联免疫吸附法(ELISA)检测上述人群中的Hp感染率。结果胃癌患者IL-1B-511 T/T基因频率及Hp感染率明显高于对照人群(P<0.05或P<0.01)。胃癌患者Hp阳性感染者IL-1B-511 T/T基因型个体显著多于对照人群。结论IL-1B-511 T/T基因型可能增加HP感染后汉族人群发生胃癌的危险性。

Objective： By comparing the stomach carcinoma patients with HP Infection Rate and IL 1B 511 gene polymorphism of the matched people, whether IL 1B 511 gene polymorphism increases the risk of stamoch cancer occurance after HP infaction. Method： RELP analysis method is adapted to examine IL 1B 511 gene polymorphism of 84 cases of stamoch carcinoma patients in low occurance rate area and that of 84 cases of normal people matched in age and sex, and ELISA is adapted to examine HP infaction rate of the above people. Restults： IL 1B 511 T/T gene frequency and HP infaction rate of stomach is higher than the control group （p 〈0. 05 or p 〈0. 01 ）. IL 1B 511 T/T genotype individual of HP positive infaction persons of stomach carcinoma patients is more than the control people. Conclusion： IL 1B 511 genotype can increase the risk of the stomach carcinoma occurance after HP infaction in the people of Han nationality.