摘要
目的:了解硝苯地平对肾性高血压患儿左室肥厚的影响。方法:超声观察18例患儿药物治疗8w前后左室重量指数(LVMI),并与15例正常儿童作比较。结果:与正常对照组(32.24±11.22g/m2)相比,治疗前患儿的LVMI增大(52.32±13.32g/m2)(P<0.05),血压增高,但年龄、血脂、血糖无显著性差异(P>0.05)。治疗后患者血压下降,LVMI显著减小(33.43±12.01g/m2)(P<0.01)。结论:硝苯地平可以在有效降低血压的同时抑制患儿左室肥厚,这一作用并不与血脂、血糖水平有关。
To study the effect of Nifedipine on the left ventricular hypertrophy in the children with renal disease accompanied by hypertension. METHOD： A total of 18 patients were given Nifedipine for 12 weeks. We detected the left ventricular mass index（LVMI） in all patients before and after treatment. 15 normal children without any treatment were taken as the control. RESULTS： Compared with the control（32.24±11.22g/m^2）, the left ventricular mass index （LVMI） （52.32±13.32g/m^2） （P〈0.05） and the blood pressure was higher in the patients before treatment. There was no significant difference in age , serum concentrations of total cholesterol or triglyceride or sugar between two groups （P〉0.05）. After treatment both the LVMI （ 33.43 ± 12.01 g/m^2 ） and blood pressure decreased in the patients （P〈0.01 ）. There was no significantly change in serum concentrations of total cholesterol , triglyceride or sugar after treatment in the sick children. CONCLUSIONS： Nifedipine could inhibit left ventricular hypertrophy and control blood pressure in the children with renal disease accompanied by hypertension being independent of the changes of serum concentrations of total cholesterol , triglyceride or sugar.
关键词
肾性高血压
硝苯地平
左室肥厚
Nifedipine Hypertension from renal disease Left ventricular hypertrophy
