摘要
目的探讨1^H—MRS在脑梗死进展中的应用价值。方法收集45例脑梗死不同进展期的MRI和MRS进行分析。结果1^H—MRS检测出脑梗死发生后不同时期脑内NAA、Cr、Cho三种代谢物含量均出现不同程度下降，以NAA下降显著，而且具有显著差异性。同时脑内会出现异常含量较高的Lac峰，其含量在脑梗死超急性期出现，急性期达高峰，以后随进程中呈逐渐下降，直至消失。依据NAA和Lac峰的变化规律可对脑梗死进行分期。结论1^H—MRS可提供脑梗死区的代谢变化，可推断脑梗死的病理生理变化、有助于早期诊断、判断预后和疗效。
Purpose ：To discussion the value of 1^H-MRS in the progress of cerebral infarction Methods： to collect the 45 cases of MR imaging diagnosis and MR spectroscopy analysis of cerebral infarction.Result： Discreased NAA, Cr, Cho,detection of Lac,no obvious change of Cr and Cho were showed in hyperacute stage of cerebral infarction,As time progress, NAA continued to decrease of even disappear,Lac continued to present in acute and subacute stage, and graduaUy disappear in chronic stage;Cr and Cho also gradually decreased,but the decreased levels of Cho were varied. Conclusion： 1^H-MRS can provide information about metabolic changes that may be useful for prediction of the rapeutic time window of cerebral infarction.
关键词
脑梗死
1^H-MRS
代谢
Cerebral infarction
MR Spectroscopy
Metabolite
