新型双球囊导管在经皮选择性隔离肝脏灌注化疗中的应用

APPLICATION OF THE NEW DOUBLE BALLOON CATHETER IN PERCUTANEOUS SELECTIVE ISOLATED HEPATIC PERFUSION CHEMOTHERAPY

目的探讨自制双球囊导管在经皮选择性肝脏隔离灌注化疗(PSIHP)中的应用效果。方法实验猪12头,利用介入放射学方法进行双球囊导管选择性隔离肝脏灌注化疗结合血液灌流。化疗药物选用5-FU。比较灌注及未灌注区域肝细胞形态和凋亡指数。结果灌注区域肝细胞损伤明显,肝细胞凋亡指数(51.82%±5.34%)明显高于未灌注区域肝细胞凋亡指数(4.12%±0.84%)(P<0.01)。结论自制新型双球囊导管能有效隔离肝脏,对未灌注区域肝组织有良好的保护作用,是一种理想的隔离肝脏灌注化疗的球囊导管。

Objective To investigate the application effects of self-made double balloon catheter in percutaneous selective isolated hepatic perfusion chemotherapy. Methods 12 pigs underwent double balloon catheter PSIHP with 5-FU by interventional radiologic method. The morphology and apoptotic index （AI） of hepatic cells of the perfusion and non-perfusion hepatic tissue were investigated. Results The hepatic cell damage was severe in the perfusion hepatic tissue and the AI was higher markedly in perfusion hepatic tissue（51.82% ± 5.34% ） compared with in non-perfusion hepatic tissue （4. 12% ± 0. 84% ） （ P 〈 0. 01 ）. Conclusion Self-made new double balloon catheter can perform effective isolated hepatic perfusion and have excellent isolation effects and satisfactory protection to non-perfusion liver, and which is a desirable balloon catheter of isolate hepatic perfusion chemotherapy.