摘要
目的检测酪氨酸激酶受体c-kit和细胞间黏附分子-1(ICAM-1)在子宫内膜异位症中的表达,探讨其在Em发病中的作用。方法用免疫组化的方法分别检测c-kit和ICAM-1在25例Em患者的异位内膜及26例正常子宫内膜上的表达,并对检测结果进行统计学分析。结果c-kit和ICAM-1二者在正常内膜表达较弱,而在异位内膜的表达较强(P<0.01);c-kit和ICAM-1在正常内膜及异位内膜中表达呈正相关,相关系数分别为r=0.682及r=0.742(P<0.01)。结论c-kit和ICAM-1在Ems患者的异位内膜的表达高及两者之间的正相关性提示其在Ems的发病发展过程中起重要的作用。
[Objectives] To investigate the association of c-kit tyrosine receptor(c-kit) and intercellular adhesion molecule-1(ICAM-1) with endometrlosis. [Methods] Immunohistochemistry was used to examine the c-kit and ICAM-1 protein expression in 26 specimens of normal endometrium,25 eetopie endometrium of endometriosis and the results were analyzed statistically. [Results] The expression of c-kit and ICAM-1 were found mainly in the stroma cells ,and ICAM-1 also expressed the glanguler epithelial cells,with the ectopie endometriotie tissue showing the higher expression than normal endometrium (P 〈0.01). C-kit and ICAM-1 expressions was positively correlated to normal and eetopie endometrium (r =0.682 and 0.742, respectively, P 〈0.01). [Conclusion] C-kit and ICAM-1 may participate in the process of the pathogenesis in endometriosis.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2008年第11期1571-1574,共4页
China Journal of Modern Medicine