三七总皂苷对急性脑梗死患者血清环氧合酶-2的影响

The Influence of Total Saponins Panax Notoginseng(PNS) on Cyclooxygenase-2 in Acute Cerebral Infarct Patients

目的探讨三七总皂苷(血栓通)对急性脑梗死患者血清环氧合酶(cyclooxygenase,COX-2)的影响。方法87例发病3d以内,符合试验入选标准的脑梗死患者随机分为实验组(n=43)和对照组(n=44),两组患者均常规应用相同的脱水剂和神经细胞活化剂,其中实验组以血栓通450mg/d静脉滴注,连续14d。分别对所有患者入院时、入院后第3d、7d和14d采集外周血,以ELISA法检测血清COX-2的水平变化,并对入院后第1d、3d、7d和14d进行神经功能缺损评分。结果入院后第3d,实验组血清COX-2的水平明显低于对照组(P<0.05),入院时及第7d以后两组比较差异无显著性意义(P>0.05);与对照组比较,实验组入院后7d、14d神经功能缺损评分明显降低(P<0.05)。结论三七总皂苷通过降低血清COX-2的水平,促进受损组织细胞的功能恢复,对急性脑梗死患者有确切的疗效。

Objective To investigate the influence of total saponins panax notoginseng （PNS） on Cyclooxygenase-2 in acute cerebral infarct patients. Methods 87 in-patients with acute cerebral in- farct were randomly divided into experimental group （n=43） and control group （n=44）, and the regular therapy were the same in two groups, but the test group is managed by the PNS therapy （450mg was administered every day for 14 times in all）. All patients during the period of the first day, 3 days, 7 days, and 14 days in hospital, blood samples were taken through vein to test the levels of COX-2 by ELISA. The Scale of Clinical Neurological Deficit （scandlnavian stroke scale, SSS） was assessed respectively on the first day, 3 days, 7 days and 14 days in hospital. Results The expression of COX-2 was significant lower in test group than that in control group on 3 day in hospital（P〈0. 05）. No significant differences could be seen in the Scale of Clinical Neurological Deficit of the first days in both groups （P〉0. 05）. Compared with the control group, the Scale of Clinical Neurological Deficit in the test group were significantly lower during the period of 7 days to 14 days （P〈0. 05）. Conclusion The PNS can reduce the level of serum COX-2 in acute infarct patients and gain the better effective therapy.