多巴胺D3受体显像剂的前体合成及其^19F的标记

Precursor synthesis and fluorine-19 labeling of dopamine D_3 receptor imagining agent

A novel dopamine D3 receptor imagining agent 7-OH-PFPAT(7-hydroxy-2-(N-propyl-N-3’-F-fluoropropionyl)aminotetralin)which has potential activity to be a dopamine D3 receptor is synthesized by multi-step reactions.At the same time,the precursor of dop-amine D3 receptor imagining agent(7-tetrahydropyranyl-2-(N-propyl-N-3’-bromopropionyl) aminotetralin) which can be radiolabeled with Fluorine-18 is prepared.The chemical structure of the target compound is confirmed by MS and 1H-NMR.This mild and easily manipulated synthetic procedure is attainable.These techniques may provide the potentiality to synthesize a radiolabeled compound 7-hydroxy-2-(N-propyl-N-3’-18F-fluoropropionyl) aminotetralin.

A novel dopaminc D3 receptor imagining agent 7-OH-PFPAT （7-hydroxy-2-（ N-propyl-N-3 ＇-F-fluoropropionyl） aminotctralin ）which has potential activity to be a dopaminc D3 receptor is synthesized by multi-step reactions. At the same time, the precursor of dop-aminc D3 receptor imagining agent （7-tctrahydropyranyl-2-（N-propyl-N-3＇-bromopmpionyl） aminotctralin） which can be radiolabeled with Fluorine-18 is prepared. The chemical structure of the target compound is confirmed by MS and ^1H- NMR. This mild and easily manipulated synthetic procedure is attainable. These techniques may provide the potentiality to synthesize a radiolabeled compound 7-hydroxy-2- （ N-propyl-N-3 ＇ -^18F-fluoropropionyl） aminotctralin.